Single-cell genomics
Building scalable methods to measure DNA methylation, chromatin accessibility, and whole genomes in individual cells.
The Adey Lab · OHSU
Measuring the epigenome.
Understanding cell identity.
We develop single-cell technologies to explore how the genome and epigenome shape cell identity, development, and disease.
Our science
A closer view of cell identity.
Research areas ↗The developing brain
Studying the epigenetic programs that guide neurodevelopment, using single-cell profiling and cerebral organoid models.
Cancer & cell states
Investigating cellular heterogeneity and how genetic and epigenetic changes relate to cancer biology.
From the lab
Latest news & discoveries
Andrew Adey on the Ion Genomics podcast
A conversation about DNA methylation, its relationship to disease, and advances in measuring it.
Listen to the episode ↗New preprint
DNA methylation dynamics in early neurodevelopment
Lauren Rylaarsdam leads work using sciMETv3 to study postnatal neuronal development and methylation changes associated with MECP2 loss.
Read the preprint ↗Amethyst: making single-cell methylation analysis accessible
Our analysis toolkit resolves distinct non-CG methylation patterns in human astrocytes and oligodendrocytes.
Read in Communications Biology ↗
People behind the science
A shared curiosity.
A collaborative lab.
Meet the researchers developing new tools and asking new questions about the biology of individual cells.